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Evaluate the clinical benchmarks from the SURPASS trials, which demonstrate significant A1C reductions and weight loss outcomes reaching 15% to 22%

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Calorie restriction with physical activity encompassing resistance exercise during weight loss has been shown to counteract high turnover bone loss compared with calorie restriction alone

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Because of this, it carries an FDA boxed warning for the risk of suicidal thoughts or behaviors during the first few months of treatment or when the dose changes