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Second, innovative nanoparticle-based delivery systems should be prioritized to increase the biodistribution and tissue-specific accumulation of therapeutic agents, thereby addressing limitations in current bioavailability

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In addition, a significant improvement in the first and second phase of insulin secretion was observed with tirzepatide treatment, as well as an improvement in beta cell function, estimated with beta-cell glucose sensitivity

Linker-dependent folding rationalizes PROTAC cell permeability

Knobloch et al., 2017, Figure 2)

The in vitro granulomas were prepared from the PBMCs isolated from blood drawn from individuals with T2DM at baseline and three months post- supplementation for both the experimental and placebo study groups