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Specifically, liraglutide did not induce ROS or increase PTX3 (an inflammatory signal) expression in endothelial cells in one study, 69 and in fact, it attenuated the increases in both ROS and PTX3 induced by TNF- , suggesting it was not increasing inflammatory activity

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In a large trial with a median follow-up of 3.8 years, liraglutide (1.78 mg) significantly reduced cardiovascular risk factors such as weight, systolic, and diastolic blood pressure

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