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Naarmate we ouderen worden neemt de aanmaak van acetylcholine af, evenals het aantal cholinerge zenuwcellen en receptoren, wat mogelijk een rol speelt bij cognitieve achteruitgang

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Substitution of bridge carbons for sulphur in calix 4 arene-bis-alpha-hydroxymethylphosphonic acid transformed mobile carrier into ionic channel accompanied with evoked muscle contraction and impaired neurotransmission powered by membrane action of resulting thiocalix 4 arene-bis-alpha-hydroxymethylphosphonic acid

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