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Kidney issues: Severe or persistent vomiting and diarrhea can lead to dehydration and kidney problems

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This is because folate supplementation may improve symptoms to the point that the B12 deficiency is not detected in tests, and therefore is not treated

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Additionally, indole-3-carboxylic acid (ICA), a metabolite derived from Lactobacillus gallinarum , has been shown to improve anti-PD-1 efficacy in mouse models with different microsatellite instability (MSI) statuses [104]