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The HCL stands for hydrochloride
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Elimination of acetaminophen is principally by liver metabolism (conjugation) and subsequent renal excretion of metabolites
After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the hydrocodone plasma concentration will decrease (see CLINICAL PHARMACOLOGY), resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to hydrocodone bitartrate and acetaminophen tablets
