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In addition, preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal (HPG) axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, concern new aspects in PCOS which are probably not always related to weight loss

Part of their defense is that the doctors knew of the side effects and had an obligation to inform the patients

Notably, it leads to a substantial reduction in the prevalence of the Proteobacteria phylum and the Gammaproteobacteria class, in turn diminishing gut inflammation