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For retirees, GLP-1 medications offer: Significant weight loss (15-21% in trials at maximum doses)

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What the evidence does not establish: Human efficacy at clinically meaningful magnitudes, long-term safety, cardiovascular profile under chronic dosing

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Consistent with the decline in proglucagon expression, GLP-1 secretion by the L-cells into the media was significantly less than the time-matched control values following exposure to carrageenan (Fig