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Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1

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Important safety considerations include a boxed warning regarding thyroid C-cell tumors observed in rodents (though the relevance to humans is unknown) and contraindications for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation