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This dramatically extends usable lifespan compared to liquid formulations, which degrade within weeks of production

Retatrutide is an investigational once-weekly injectable medication

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Its levels are normally very low in most tissues but are rapidly up-regulated during the inflammatory process by proinflammatory substances (e.g., cytokines, endotoxins, and tumor promoters)

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In this way, our study extends previous descriptive observations of biodegradable MP neurotoxicity to a mechanistic level [35], identifying microglial lipotoxicity as a previously unrecognized link between intestinal PBAT-MPs exposure and neuronal dysfunction