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Nonobese PCOS populations Few trials have explored the use of metformin in nonobese populations with PCOS

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It is a dual GLP-1 and GIP receptor agonist, the same mechanism class as tirzepatide, but engineered for once-monthly subcutaneous administration instead of weekly

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While results were somewhat beneficial for certain subgroups, the overall effects were not statistically significant, indicating that more robust studies are needed