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Schlegel for their contribution to the peer review of this work

64 In a randomized, double-blind pilot study that assessed the impact of adding silymarin (420 mg/day) to standard chemotherapy on the clinical response of advanced malignancies following three cycles of cisplatin-based chemotherapy, a tendency of decreased metastasis rate in the chemotherapy plus silymarin group was reported though there was no significant variance in tumor size

10.1039/c0dt01176b Dalton Trans

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You're experiencing diminishing nausea or appetite suppression (the medication effect is fading), yet your weight isn't changinga classic sign of adaptation