glp-1 obesity drug market forecast 2030 GLP-1 Drugs Revolutionize Weight Loss

doi: 10.1515/chem-2020-0050 51 GrygorievaO.KlymenkoS.KuklinaA.VinogradovaY.VergunO.SedlackovaV

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Examples are MTHFR variants, which impact folate metabolism and homocysteine, FTO and MC4R, which are associated with weight regulation, CYP19A1, which is involved in aromatase and estrogen balance, ESR1 and ESR2, which are estrogen receptors, and variants in FSHR and LHCGR that alter ovarian response

Long-term safety characterization, published safety data is limited to short-duration animal studies

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Clinical evidence shows LDL reductions of 510% and triglyceride improvements of 1525% in most patients, with better results in those who achieve significant weight loss