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The key clinical, translational, perioperative, economic, and implementation-related evidence informing this proposed framework is summarized and critically appraised in Table 1, which also distinguishes direct human KOA evidence from indirect, observational, and hypothesis-generating evidence

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At the onset of adrenal fatigue, we lose sodium and potassium

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The last type is discoid/bidiscoid, confined to a roughly circular area and seen in primates, rodents, and rabbits (4)