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However, these in vitro studies often use relatively high Mn concentrations (up to 1 mM), exceeding physiological brain Mn levels, but acute culture systems generally require higher doses to reveal mechanistic effects in the absence of the physiological environment

This would be equal to 0.8mg/daily for a 175lb test subject [13]

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The cells were then incubated with 100 M of -EC and GSH standards and the extract containing 100 M -EC for 4 h

In addition, as was previously reported, we observed an increase in the expression of SOD2, which is known to be involved in the mitochondrial oxidative stress pathway 14

RNAi suppression of Arogenate Dehydratase1 reveals that phenylalanine is synthesized predominantly via the arogenate pathway in petunia petals