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Drug Interactions Drug Interactions Affecting Co-administered Drugs: Antibiotics: Thiamine, riboflavin, pyridoxine, niacinamide and ascorbic acid decrease activities of erythromycin, kanamycin, streptomycin, doxycycline and lincomycin (7.1) Bleomycin: Ascorbic acid and riboflavin may reduce the activity of bleomycin (7.1) Levodopa: Pyridoxine may decrease blood levels of levodopa and levodopa efficacy may decrease (7.1) Phenytoin: Folic acid may decrease phenytoin blood levels and increase risk of seizure (7.1) Methotrexate: Folic acid may decrease response to methotrexate (7.1) Drug Interactions Affecting Vitamin Levels: Use In Specific Populations See 17 for PATIENT COUNSELING INFORMATION

While the thigh is a common area for intramuscular injections, you can also inject subcutaneously if you have enough fat there

Expectation misalignment Expecting dramatic results in the first week sets up disappointment

Let it approach room temperature to reduce injection discomfort