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To move out of that protective state, the tissue needs consistent signals that support: adequate circulation and nutrient delivery controlled inflammatory signaling organized cell migration into damaged areas high-quality collagen synthesis and alignment progressive mechanical loading without repeated flare cycles This is where GLOW fits

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Their beneficial mechanisms can include the attenuation of neuroinflammation [e.g., valproate via histone deacetylase (HDAC) inhibition in microglia, downregulating interleukin-1 beta (IL-1) and inducible nitric oxide synthase (iNOS)] or the mitigation of glutamatergic excitotoxicity coupled with enhancement of neurotrophic factor expression (e.g., lamotrigine), thereby conferring antidepressant-like potential (Mula and Sander, 2007

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Daud MK, Mei L, Azizullah A, Dawood M, Ali I, Mahmood Q, Ullah W, Jamil M, Zhu SJ