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10.1677/joe.0.1680001 14

doi: 10.1016/j.ijbiomac.2020.08.255 18 LiuZJiaoYWangYZhouCZhangZ

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In the recent trial, participants on the highest 36-milligram dose had about a 2 percent greater risk of a serious adverse event, compared with those given a placebo

From an aesthetic perspective, this matters because: GLP-1 RAs influence body composition, reducing lean mass, which might alter diffusion or uptake of injectables They impact systemic metabolism which may alter the pharmacokinetics or pharmacodynamics of other drugs As more patients on GLP-1 therapy request cosmetic injectables, including botulinum toxin, the potential for interaction becomes clinically relevant