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In the case of individuals intending to conceive, the use of metformin may be continued until pregnancy is confirmed, whereas for those not actively pursuing pregnancy, metformin may be administered until normalization of glucose regulation is achieved

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Women taking oral contraceptives may show decreased cobalamin levels because of a decrease in cobalamin carrier protein, however, this may not result in a deficiency

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10.1038/s41419-018-1099-3 16 DongW.LiH.LiY.WangN.MaB.LuG.-L.et al (2021)