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GHK-Cus levels decline with age, contributing to visible signs of skin aging

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In intact cells, activation of NFT yielded a radical anion, which subsequently initiated nuclear-factor-erythroid 2-related-factor-2 (Nrf2)-dependent induction of glutamate cysteine ligase (GCL)

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For all four tested residues, we found that depending on the substitution introduced, the two enzymatic activities were impacted to different extents (Fig