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NOX2 expression is additionally elevated in the brain following TBI and in epilepsy as reviewed by Ma et al., 2018

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However, it's important to note that glutathione is susceptible to breakdown in the stomach's acidic environment

Enteral Routes (Via Gastrointestinal Tract) Oral (PO) Most common and convenient route Drug absorbed mainly in the small intestine Subject to first-pass metabolism (liver) Clinical Insight: Suitable for chronic therapy but not ideal in vomiting/unconscious patients Sublingual / Buccal Absorption through oral mucosa Bypasses first-pass metabolism Rapid onset Example: Nitroglycerin in angina Rectal Used when oral route is not feasible Partial avoidance of first-pass metabolism Limitation: Erratic absorption 2

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