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Reduced NNMT in adipose tissue was associated with increased expression of polyamine flux genes and increased adipocyte energy expenditure connecting NNMT inhibition to "futile cycling" mechanisms that consume energy without productive metabolic output

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Research shows that targeting NNMT could help in treating these conditions by improving how the body uses energy, reducing fat, and bettering insulin sensitivity

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The more active you are, the better your metabolism will function and the more calories you will burn, which can help you lose weight

(2018) Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy