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In a randomised controlled trial with over 1800 participants comparing tirzepatide to semaglutide, the tirzepatide group reported more serious adverse events (5-7% VS 3%) and higher discontinuation rates due to adverse events (6-8.5% VS 4%)

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The non-coded amino acid residues incorporated at positions 2, 20, and 13 provide resistance to enzymatic degradation while maintaining receptor-binding affinity across all three target receptors