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Although insulin is a powerful regulator of lipid metabolism, the acute lipid-lowering actions of GLP-1 have been shown to be mediated independent of changes in islet hormones and glucose and free fatty acid levels in mice and humans (9, 26)

Propionate-induced gut hormone release is attenuated in FFA2 / primary murine L cells To evaluate the role of FFA2 in mediating propionate-induced PYY and GLP-1 secretion, we examined the effect of propionate on gut hormone secretion from primary colonic cultures from FFA2-deficient mice (FFA2 / )

The FDA-approved starting dose of injectable semaglutide for weight loss is 0.25 mg once weekly

Subcutaneous weekly semaglutide with automated insulin delivery in type 1 diabetes: a double-blind, randomized, crossover trial

(126) observed that GLP-1R signaling exerted more robust control of -cell survival, relative to GIPR activation