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One of the most significant contributors to aging and disease is oxidative stress, a condition caused by an imbalance between free radicals and antioxidants in the body

Society for Experimental Biology and Medicine (New York, N.Y.) vol

Gangadin and J.m Steiner for reviewing some sections outside the formal review process

In a mouse model, central infusion of recombinant TNF- , when combined with sub-threshold noise exposure, synergistically promoted microglial activation, loss of parvalbumin-positive inhibitory neurons in the AC, and induced auditory processing deficits and tinnitus-like behaviors, which were not observed with either insult alone (Deng et al., 2020b)

In particular, oxidative stress caused by reactive oxygen species (ROS) is a major contributor to the pathophysiology of neurodegenerative diseases