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All authors of the manuscript have read and approved the MS of this paper and declare that it has not been published previously nor is it being considered by any other peer-reviewed journal

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Conclusion Our findings demonstrate that all three GLP-1 analogs, semaglutide, tirzepatide, and retatrutide, exhibit significant anti-obesity effects in MC4R KO mice

These natural approaches may provide metabolic benefits, but their effects are generally much smaller in magnitude compared to prescription GLP-1 receptor agonists like semaglutide

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