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Unlike traditional fat-loss compounds, it is being studied as a non-stimulant option

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Insulin and other glucose-lowering drugs may need adjustment to reduce hypoglycemia risk

Direct activation of the melanocortin-4 receptor in the hypothalamus with melanocortin-4 receptor agonist setmelanotide resulted in significant weight loss in small clinical studies conducted in severely obese individuals with pro-opiomelanocortin deficiency or other rare congenital conditions affecting the melanocortin-4 signaling pathway [123]

I think eventually were going to need to do complication-specific clinical trials, as I mentioned, where its the improvement in the complication is the primary outcome measure, not amount of weight loss per se