demonstrated dose-dependent proliferation effects on cultured human dermal papilla cells exposed to GHK-Cu at physiologically relevant concentrations.3 Subsequent work has confirmed that this effect translates into upregulation of genes associated with anagen-phase activity including VEGF, FGF-2, and IGF-1, the three growth factors most directly implicated in hair-cycle regulation
Both require further human clinical trials to fully establish their therapeutic potential, though GHK-Cu's existing commercial use in dermatology provides some real-world validation of its skin-related applications
The takeaway here is that GHK-Cu is structural and slow
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Lipoic acid is available as a dietary supplement without a prescription in the US
They noted that, despite the consistent lack of statistical power in the body of literature on this topic, None of the trials reported evidence of significant decreases in efficacy from antioxidant supplementation during chemotherapy