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Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones

They encapsulated ER degrader ERD308 and CDK4/6 inhibitor palbociclib within pH-sensitive MPEG-poly(-amino ester) micelles, which were then incorporated into biodegradable microneedles patches (Fig

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Since these medications are still fairly new, we dont know all the possible long-term effects or risks