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One commonly cited example is insulin, a naturally occurring peptide with a well-understood structure and function in glucose regulation, studied extensively in biochemical research

On the one hand, IL-1 exacerbates BBB disruption by downregulating tight junction protein Zonula Oc-cludens-1 (ZO-1), activating caspase-1 within the brain, and establishing a positive feedback loop that amplifies IL-1 production (36)

doi: 10.1210/jc.2016-1473 16 MollerLDalmanLNorrelundHBillestrupNFrystykJMollerNet al

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