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The typical Western diet, low in fiber and high in processed foods, dramatically reduces butyrate-producing bacteria

The most common included diarrhea, nausea and constipation, which are also seen across the broader GLP-1 class

It is a long-acting peptide with an approximate half-life of six days and is administered via subcutaneous injection, enabling once-weekly dosing in trials

Both produce satiety, but in different brain regions

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Which Interventions Reduce Side Effects in Practice The evidence points consistently in one direction: most GI side effects are manageable, and how they are managed determines whether patients stay on treatment long enough to benefit