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It targets the histidine sensor kinase QseC, a receptor in a broad spectrum of pathogens, inhibiting downstream QseC-mediated production of virulence factors

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Psoriatic arthritis nails show pitting (small depressions across the nail surface), onycholysis (separation of the nail from the nail bed), subungual hyperkeratosis (thickening under the nail), and oil drop discolouration (a yellowish patch visible through the nail)

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The most unexpected and intriguing finding of this study concerns the redox states of ROXY9 and class I GRXs GRXC2 and HsGRX1 observed in redox titration experiments with either DTT/dithiane or GSSG/GSH at p H 7 (Fig