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However, despite adequate protocols, methodological flaws such as lack of randomization, concealment of allocation, lack of blinded outcome evaluation, and high heterogeneity in the doses used in supplementation, as well as among the included studies, can compromise the level of evidence generated in this systematic review

Gbefon CY, Sobral CPS, Caldas A, Rocha VCC, Azulay RSS, Nascimento GC, et al

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Expression and functions of the vitamin D in the skin Active Vitamin D exerts multilayered regulatory effects in the skin through its nuclear receptor, VDR, and these effects exhibit pronounced cell-type specificity

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Find the acromion bone on top of your shoulder and go two to three finger-widths below it, into the thickest part of the deltoid