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Renal cells in the context of ADPKD exhibit a wide range of metabolic abnormalities, including the decreased expression of system Xc- and reduced activity of GPX4, which are the necessary conditions and typical characteristics of ferroptosis [252, 253]

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Probiotics, like Probiotic-4, which comprises strains like Bifidobacterium lactis and Lactobacillus acidophilus, have been observed to decrease IL-6 levels, a cytokine negatively correlated with longevity [25]

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