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The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models

While both promote neural repair, they engage entirely different growth factor systems

1 week after the surgery was performed the rats were administered manual physiotherapy to the right hind limb 1-2 times per week for 5 minutes at a time