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Pediatr Res 19:459466 Frye RE, Melnyk S, Macfabe DF (2013) Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder

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However, their efficacy is context-dependent, with DHA demonstrating relatively consistent anti-fibrotic effects in preclinical models, curcumin exhibiting formulation- and bioavailability-dependent benefits, and EPA and vitamin D showing variable responses across studies and disease stages