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Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit

On the contrary, anti-TPO antibodies were slightly increased, without reaching statistical significance

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A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification