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Over time, this can contribute to changes in different organs and tissues, especially in younger cancer survivors who may live for many decades after treatment

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AMPK activation, mTOR pathway inhibition

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Treatment duration proves critical variable where longer courses create more durable changes - users completing 2-3 month treatments typically maintain 20-40% of peak benefits long-term, 4-6 month treatments sustain 40-60% of improvements, and 6-12+ month courses preserve 50-70% of maximum benefits potentially indefinitely