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Significantly, it has been demonstrated that GLP-1 analogues can suppress NF-B, which is a major activator of IL-6 expression [121]

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A major challenge in the industrial-scale synthesis of ziconotide lies in (a) achieving a high-yield synthesis of the linear 25-mer precursor, and (b) promoting efficient, native disulfide bond formation

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Neurological function, inflammatory infiltration, oligodendrocyte progenitor cells (OPCs), and mature oligodendrocytes were measured in the brains of EAE mice