Cells 11 , 1883 (2022)
The SELECT trial (2023) demonstrated that Wegovy significantly reduces major adverse cardiovascular events (MACE) heart attack, stroke, cardiovascular death in patients with established cardiovascular disease and obesity
In the light of the current research, it is speculated that the maladaptive changes in the gut microbiota can influence the central nervous system and evoke depressive symptoms, and the development of depression can influence gut microbiome stability, and both of these hypotheses appear to be supported by the results of human and animal studies [100]
Results showed that under 24% of GLP-1 users needed ER care, compared with more than 26% of those on topiramate
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[1] [2] Short-chain fatty acids (primarily acetic, propionic, and butyric acids), which microganisms form in the intestines, bind to the FFAR2 and FFAR3 receptors on K cells and L cells to stimulate their respective production and secretion of GIP [3] and GLP-1