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Tchang says, [a] slower gut may predispose them to constipation and reflux. Researchers also hypothesized that the lower average body weight of females (when compared to males) allows for more exposure to the drugs active ingredient

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Improvements in Drug Delivery In studies with mice, the research team, led by Bradley Pentelute, a professor of chemistry at MIT, found that their new drug delivery system resulted in sustained weight loss and extended blood sugar management

E.De ChiaraG.FraternaleA.et al (2019)