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doi: 10.1177/02537176241246744

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SIRT1 upregulates the expression of NRF2 target antioxidant genes, including mitochondrial antioxidant manganese superoxide dismutase (MnSOD), catalase, heme oxygenase-1 (HO-1), and glutathione ( FOXOs Signaling PathwayGeneral Remarks An impressive class of transcription factors for cancer therapeutic modulation is represented by the forkhead box transcription factors (FOXO) family