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It should be noted that alanine mutations of F279 6.51 and F312 7.42 partly maintain the binding of ghrelin but remarkably diminish its activity, indicating that these phenylalanines are mainly responsible for signal transmission (Fig

Human and non-human trials have also noted occurrences of non-gastrointestinal side effects including allergic reactions, hypoglycemia, diabetic retinopathy complications, c-cell tumors, acute kidney injury and worsening of chronic renal failure

Eur Heart J 1984;5(Abstr Suppl 1):138

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