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Evidence suggests multiple interrelated pathways of liver injury: Nicotine-induced injury : Nicotine is metabolized in the liver via CYP2A6, where it activates 7-nicotinic acetylcholine receptors (7-nAChR), leading to oxidative stress, mitochondrial dysfunction, and pro-fibrotic signaling [36, 125, 126]

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doi: 10.1186/s13048-019-0500-x 175 ArendtJAulinasA

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Treatment Insights Based on Prognostic and Predictive Markers such as KRAS, BRAF, NRAS and PIK3C, other RAS Mutations, and DNA Mismatch Repair for Patients with Metastatic Colorectal Cancer

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