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This paper provides compelling evidence for an inside-out mode of parasite egress

This yellowing takes place due to the high bilirubin levels, presence of a compound called coproporphyrin in the urine, and reduced ability of the liver to take up certain chemicals known as anionic diagnostics, including a specific tracer used in liver imaging called cholescintigraphic tracers

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His clinical status improved and the analgesics were discontinued

Bradshaw JW, McPherson JA, Casey RA, Larter S

The treatments are administered either as injections from daily to weekly or as pills to be taken once a day or twice with meals