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Effect on biomarkers of aging and life span in Swiss mice PubMed Induces telomerase activity and telomere elongation in human somatic cells PubMed Storage Handling & stability

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Upon copper transfer from Atox1 to CRIP2, CRIP2 undergoes secondary structural changes, ultimately promoting its ubiquitin-mediated protein degradation

5.2 Copper-based systems The co-delivery of resveratrol with copper-based systems represents an emerging strategy in cancer therapeutics, leveraging the unique redox chemistry of copper ions and the multifaceted pharmacological properties of resveratrol

Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig