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The STEP 1 trial (N=1,961) published in the New England Journal of Medicine in 2021 (DOI: 10.1056/NEJMoa2032183) demonstrated 14.9% mean body weight reduction with semaglutide 2.4mg weekly versus 2.4% with placebo over 68 weeks

Always inject water slowly down the vial wall

Phase 2 jumped from 4 mg straight to 8 mg

The DREAMS-3 trial put mazdutide directly against semaglutide in a head-to-head comparison

If the FDA changes guidance, restricts, or removes access to any compounded preparation, Vesta will discontinue that preparation in alignment with federal regulation

Importantly, even though total lean mass decreased, the proportion of lean mass relative to total body weight actually increased in semaglutide patients