The duration of therapy varies depending on the indication and patient response, with some protocols recommending treatment for several weeks to months
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As the volume of aerated lung is reduced in patients with SARS, even the normal volumes delivered with airway pressures surveyed for the uninjured lung can cause volumetric trauma, further damaging the epithelium and stimulating inflammation
More specifically, several recurring TME features are particularly relevant to nanotherapeutic design: abnormal vasculature, dense stroma and an immunosuppressive immune landscape [10,11,12,13,14]
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