Similarly, silencing PDK1/2 , key PDH inhibitory kinases, lowers these lactylation levelsan effect that is reversible upon exogenous L-lactate incubation [67]
In this matter, astrocytes are essential for the regulation of oxidative stress and ROS production, both in normal and in pathological circumstances
The G/D-CuP group exhibited a markedly elevated SOD activity compared to the G/M-CuP group, indicating improved antioxidant capacity (Fig
However, excess activity has negative effects on metabolic balance and regulation
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