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Molecular durability is achieved through peptide engineering strategies that (i) confer resistance to DPP-4 cleavage, typically via N-terminal modification, and/or (ii) extend systemic exposure through fatty-acid acylation, which enhances albumin binding and slows renal clearance, thereby prolonging receptor activation [18]

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doi: 10.1172/JCI116186 30 NauckMAKleineNOrskovCHolstJJWillmsBCreutzfeldtW

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Sample sizes ranged from 24 to 252 participants, with larger studies often exploring long-term preventive effects of GLP-1

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